Contact information
robin.choudhury@cardiov.ox.ac.uk
+44 (0)1865 234664
Miss Eunice Berry
eunice.berry@cardiov.ox.ac.uk
Colleges
DPHIL SUPERVISOR PROFILE
Robin Choudhury
MA DM FRCP
Professor of Cardiovascular Medicine
- Honorary Consultant Cardiologist
- Fellow in Biomedical Sciences, Balliol
Integrative Physiology (Systems Biology)
Overview
This translational science laboratory aims to understand how cells of the innate immune system are involved in processes of tissue homeostasis, injury and repair.
Areas of particular interest focus around: (1) understanding the role of monocytes, macrophages and neutrophils in acute myocardial infarction; myocardial regeneration vs repair and in atherosclerosis and (2) how these cells are 'programmed' e.g. by extracellular vesicles and through by genetic / epigenetic and metabolic mechanisms.
Robin Choudhury qualified in medicine at the University of Oxford with postgraduate training in London (Royal Brompton & Hammersmith) and at Mount Sinai School of Medicine, New York. He is currently Professor of Cardiovascular Medicine at the University of Oxford; Consultant Cardiologist to the John Radcliffe Hospital and Research Fellow in Biomedical Sciences at Balliol.
He is co-PI of of the NovoNordisk Foundation supported Metabolite-related inflammation and disease (MeRIAD) consortium. He serves on the Editorial Board of the Journal of the American Journal of Cardiology (Section Editor, Clinical Cardiology).
Key publications
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Inflammatory processes in cardiovascular disease: a route to targeted therapies.
Journal article
Ruparelia N. et al, (2017), Nat Rev Cardiol, 14, 133 - 144
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Arterial effects of canakinumab in patients with atherosclerosis and type 2 diabetes or glucose intolerance
Journal article
Choudhury RP. et al, (2016), Journal of the American College of Cardiology, 68, 1769 - 1780
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Differential Gene Expression in Macrophages From Human Atherosclerotic Plaques Shows Convergence on Pathways Implicated by Genome-Wide Association Study Risk Variants
Journal article
CHOUDHURY R., (2018), ATVB
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Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics
Journal article
(2018), Nature Reviews Drug Discovery
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Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans.
Journal article
Ruparelia N. et al, (2015), Eur Heart J, 36, 1923 - 1934
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Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction.
Journal article
Akbar N. et al, (2017), JCI insight, 2
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Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis.
Journal article
Edgar L. et al, (2021), Circulation
Recent publications
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Automated 3D Whole-Heart Mesh Reconstruction From 2D Cine MR Slices Using Statistical Shape Model.
Conference paper
Banerjee A. et al, (2022), Annu Int Conf IEEE Eng Med Biol Soc, 2022, 1702 - 1706
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Neuropeptide-Y Levels in ST-Segment-Elevation Myocardial Infarction: Relationship With Coronary Microvascular Function, Heart Failure, and Mortality.
Journal article
Gibbs T. et al, (2022), J Am Heart Assoc
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Rapid neutrophil mobilisation by VCAM-1+ endothelial extracellular vesicles.
Journal article
Akbar N. et al, (2022), Cardiovasc Res
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Discordant Genome Assemblies Drastically Alter the Interpretation of Single-Cell RNA Sequencing Data Which Can Be Mitigated by a Novel Integration Method
Journal article
Potts HG. et al, (2022), Cells, 11