Websites
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MRC Molecular Haematology Unit
Research Unit
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MRC Weatherall Institute of Molecular Medicine
Research Institute
Roger Patient
Visiting Professor of Developmental Genetics
Blood and cardiovascular development, with a particular focus on stem cells. Transcriptional network assembly in response to embryonic signals. Xenopus and zebrafish models.
Key publications
MiR-142-3p controls the specification of definitive hemangioblasts during ontogeny
Journal article
Nimmo R. et al, (2013), Developmental Cell, 26, 237 - 249
VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus.
Journal article
Ciau-Uitz A. et al, (2013), Development, 140, 2632 - 2642
Uncoupling VEGFA functions in arteriogenesis and hematopoietic stem cell specification.
Journal article
Leung A. et al, (2013), Dev Cell, 24, 144 - 158
Recent publications
The roles and controls of GATA factors in blood and cardiac development
Conference paper
Patient R. et al, (2019)
Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium.
Journal article
Bonkhofer F. et al, (2019), Nat Commun, 10
n optimised pipeline for parallel image-based quantification of gene expression and genotyping after in situ hybridisation
Journal article
(2019), Biology Open
Etv6 activates vegfa expression through positive and negative transcriptional regulatory networks in Xenopus embryos.
Journal article
Li L. et al, (2019), Nat Commun, 10
New methods for computational decomposition of whole-mount in situ images enable effective curation of a large, highly redundant collection of Xenopus images.
Journal article
Patrushev I. et al, (2018), PLoS Comput Biol, 14