Store-Operated Ca2+ Channels: Mechanism, Function, Pharmacology, and Therapeutic Targets.
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Bakowski D. et al, (2020), Annu Rev Pharmacol Toxicol
Single nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression.
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Yeh Y-C. et al, (2019), Hum Mol Genet
Calcium signalling in health and disease.
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Parekh AB., (2019), Seminars in Cell and Developmental Biology
Selective recruitment of different Ca2+-dependent transcription factors by STIM1-Orai1 channel clusters.
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Lin Y-P. et al, (2019), Nat Commun, 10
The whole cell Ca2+ release-activated Ca2+ current ICRAC is regulated by the mitochondrial Ca2+ uniporter channel and is independent of extracellular and cytosolic Na
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Samanta K. et al, (2018), The Journal of Physiology, 00, 1 - 21
New insights into Ca2+ channel function in health and disease.
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Fleig A. and Parekh AB., (2018), The Journal of Physiology, 595, 2997 - 2998
The allergen Der p3 from house dust mite stimulates store-operated Ca2+ channels and mast cell migration through PAR4 receptors
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Parekh AB., (2018), Molecular Cell
Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria
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Samanta K. et al, (2018), Nature Communications, 9, 156 - 156
Spatial Ca2+ profiling: decrypting the universal cytosolic Ca2+ oscillation.
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Samanta K. and Parekh AB., (2017), J Physiol, 595, 3053 - 3062
Regulation of CRAC channels by Ca2+-dependent inactivation.
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Parekh AB., (2017), Cell Calcium, 63, 20 - 23
Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca(2+) Signals.
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Kar P. et al, (2016), Molecular Cell, 64, 746 - 759
Store-operated Ca2+ channels in airway epithelial cell function and implications for asthma.
Journal article
Samanta K. and Parekh AB., (2016), Philos Trans R Soc Lond B Biol Sci, 371
Ca2+ Influx through Store-operated Calcium Channels Replenishes the Functional Phosphatidylinositol 4,5-Bisphosphate Pool Used by Cysteinyl Leukotriene Type I Receptors.
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Alswied A. and Parekh AB., (2015), J Biol Chem, 290, 29555 - 29566
Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression.
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Samanta K. et al, (2015), Cell Rep, 12, 203 - 216
Distinct spatial Ca2+ signatures selectively activate different NFAT transcription factor isoforms.
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Kar P. and Parekh AB., (2015), Mol Cell, 58, 232 - 243
Distinct structural domains of caveolin-1 independently regulate Ca2+ release-activated Ca2+ channels and Ca2+ microdomain-dependent gene expression.
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Yeh Y-C. and Parekh AB., (2015), Mol Cell Biol, 35, 1341 - 1349
Caveolin-1 alters the pattern of cytoplasmic Ca2+ oscillations and Ca2+-dependent gene expression by enhancing leukotriene receptor desensitization.
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Yeh Y-C. et al, (2014), J Biol Chem, 289, 17843 - 17853
Dynamic assembly of a membrane signaling complex enables selective activation of NFAT by Orai1.
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Kar P. et al, (2014), Curr Biol, 24, 1361 - 1368
An introduction to the Bioscience Birthday Symposium held in honour of Ole Petersen CBE, FRS.
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Parekh AB., (2014), J Physiol, 592, 259 - 260
Key role for store-operated Ca2+ channels in activating gene expression in human airway bronchial epithelial cells.
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Samanta K. et al, (2014), PLoS One, 9