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Publications

Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy.

Vuorinen A. et al, (2021), Eur J Med Chem, 220

Structural Requirements for Dihydrobenzoxazepinone Anthelmintics: Actions against Medically Important and Model Parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni.

Partridge FA. et al, (2021), ACS Infect Dis

Decreasing HepG2 Cytotoxicity by Lowering the Lipophilicity of Benzo[d]oxazolephosphinate Ester Utrophin Modulators.

Chatzopoulou M. et al, (2020), ACS Med Chem Lett, 11, 2421 - 2427

Combining experimental strategies for successful target deconvolution.

Wilkinson IVL. et al, (2020), Drug Discov Today

Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family.

Quevedo CE. et al, (2020), Bioorg Med Chem, 28

2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy.

Babbs A. et al, (2020), J Med Chem

The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes

ISSA F. and HESTER J., (2020), Blood

Molecular Mechanism of Modulation of the TMEM16A Channel by Anthracene-9-Carboxylic Acid: Implications for Channel Gating

Dinsdale R. et al, (2020), BIOPHYSICAL JOURNAL, 118, 325A - 325A

A Semiautomated, Phenotypic, In Vitro Scratch Assay for Assessing Retinal Pigment Epithelial Cell Wound Healing.

Storm T. et al, (2020), J Ocul Pharmacol Ther

Anthelmintic drug discovery: target identification, screening methods and the role of open science.

Partridge FA. et al, (2020), Beilstein journal of organic chemistry, 16, 1203 - 1224

Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.

Wilkinson IVL. et al, (2019), Angew Chem Int Ed Engl

Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase.

Wilkinson IVL. et al, (2019), Bioorg Chem

Isolation, structural identification, synthesis, and pharmacological profiling of 1,2-trans-dihydro-1,2-diol metabolites of the utrophin modulator ezutromid.

Chatzopoulou M. et al, (2019), J Med Chem

A biased agonist at immunometabolic receptor GPR84 causes distinct functional effects in macrophages.

Lucy D. et al, (2019), ACS Chem Biol

Target identification studies of a utrophin modulator for treatment of Duchenne muscular dystrophy

Wilkinson I. et al, (2019), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 257

Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.

Cruz-Migoni A. et al, (2019), Proceedings of the National Academy of Sciences of the United States of America

Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model

Babbs A. et al, (2019), Tetrahedron

The Dimroth rearrangement as a probable cause for structural misassignments in imidazo[1,2-a]pyrimidines: A<sup>15</sup>N-labelling study and an easy method for the determination of regiochemistry

Chatzopoulou M. et al, (2018), Tetrahedron, 74, 5280 - 5288

Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors.

Stefaniak J. et al, (2018), ACS chemical biology

Small molecule utrophin modulators for the therapy of Duchenne muscular dystrophy (DMD)

Russell A. et al, (2018), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 256

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