Decreasing HepG2 Cytotoxicity by Lowering the Lipophilicity of Benzo[d]oxazolephosphinate Ester Utrophin Modulators.
Journal article
Chatzopoulou M. et al, (2020), ACS Med Chem Lett, 11, 2421 - 2427
Combining experimental strategies for successful target deconvolution.
Journal article
Wilkinson IVL. et al, (2020), Drug Discov Today
Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family.
Journal article
Quevedo CE. et al, (2020), Bioorg Med Chem, 28
2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy.
Journal article
Babbs A. et al, (2020), J Med Chem
The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes
Journal article
ISSA F. and HESTER J., (2020), Blood
Molecular Mechanism of Modulation of the TMEM16A Channel by Anthracene-9-Carboxylic Acid: Implications for Channel Gating
Conference paper
Dinsdale R. et al, (2020), BIOPHYSICAL JOURNAL, 118, 325A - 325A
A Semiautomated, Phenotypic, In Vitro Scratch Assay for Assessing Retinal Pigment Epithelial Cell Wound Healing.
Journal article
Storm T. et al, (2020), J Ocul Pharmacol Ther
Anthelmintic drug discovery: target identification, screening methods and the role of open science.
Journal article
Partridge FA. et al, (2020), Beilstein journal of organic chemistry, 16, 1203 - 1224
Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid.
Journal article
Wilkinson IVL. et al, (2019), Angew Chem Int Ed Engl
Characterisation of utrophin modulator SMT C1100 as a non-competitive inhibitor of firefly luciferase.
Journal article
Wilkinson IVL. et al, (2019), Bioorg Chem
Isolation, structural identification, synthesis, and pharmacological profiling of 1,2-trans-dihydro-1,2-diol metabolites of the utrophin modulator ezutromid.
Journal article
Chatzopoulou M. et al, (2019), J Med Chem
A biased agonist at immunometabolic receptor GPR84 causes distinct functional effects in macrophages.
Journal article
Lucy D. et al, (2019), ACS Chem Biol
Target identification studies of a utrophin modulator for treatment of Duchenne muscular dystrophy
Conference paper
Wilkinson I. et al, (2019), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 257
Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds.
Journal article
Cruz-Migoni A. et al, (2019), Proceedings of the National Academy of Sciences of the United States of America
Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model
Journal article
Babbs A. et al, (2019), Tetrahedron
The Dimroth rearrangement as a probable cause for structural misassignments in imidazo[1,2-a]pyrimidines: A<sup>15</sup>N-labelling study and an easy method for the determination of regiochemistry
Journal article
Chatzopoulou M. et al, (2018), Tetrahedron, 74, 5280 - 5288
Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors.
Journal article
Stefaniak J. et al, (2018), ACS chemical biology
Small molecule utrophin modulators for the therapy of Duchenne muscular dystrophy (DMD)
Conference paper
Russell A. et al, (2018), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 256
Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Journal article
Quevedo CE. et al, (2018), Nat Commun, 9
Correction: BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions.
Journal article
Bery N. et al, (2018), eLife, 7