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Publications

Cardiomyocyte tetrahydrobiopterin synthesis regulates fatty acid metabolism and susceptibility to ischaemia-reperfusion injury.

Chu SM. et al, (2023), Exp Physiol, 108, 874 - 890

Role of Human Epicardial Adipose Tissue-Derived miR-92a-3p in Myocardial Redox State

BADI I., (2023), Journal of the American College of Cardiology

Crucial neuroprotective roles of the metabolite BH4 in dopaminergic neurons.

Cronin SJF. et al, (2023), bioRxiv

Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury.

Chuaiphichai S. et al, (2023), Am J Physiol Heart Circ Physiol, 324, H430 - H442

Endothelial cell vasodilator dysfunction mediates progressive pregnancy-induced hypertension in endothelial cell tetrahydrobiopterin deficient mice.

Chuaiphichai S. et al, (2023), Vascul Pharmacol, 150

Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2

Broadway-Stringer S. et al, (2023), Cells

Human epicardial adipose tissue-secreted miR-92a-3p regulates myocardial redox state via paracrine signalling: implications for cardiovascular clinical outcomes

Badi I. et al, (2023), EUROPEAN HEART JOURNAL, 44

Crucial functions of alpha-actinin 2 in the embryonic heart

Gehmlich K. et al, (2022), CARDIOVASCULAR RESEARCH, 118

PHACTR1 modulates vascular compliance but not endothelial function: a translational study.

Wood A. et al, (2022), Cardiovasc Res

Deletion of tetrahydrobiopterin synthesis in cardiomyocytes causes downregulation of fatty acid metabolism whilst protected against cardiac ischemia reperfusion injury

Chu S. et al, (2022), JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 173, S125 - S125

Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma

BISHOP T., (2021), Endocrine-Related Cancer

Endothelial GTP Cyclohydrolase and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling and Fetal Growth

CHUAIPHICHAI S. et al, (2021), Hypertension

Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition

AKOUMIANAKIS I. et al, (2020), Science Translational Medicine

A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.

Douglas G. et al, (2019), Cardiovasc Res

Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17//RAC1-mediated activation of NADPH oxidases

AKOUMIANAKIS I. et al, (2019), Science Translational Medicine

Nox2 contributes to age-related oxidative damage to neurons and the cerebral vasculature.

Fan LM. et al, (2019), J Clin Invest, 130

Deficiency in endothelial cell tetrahydrobiopterin increases resistance vascular remodelling, blood pressure, and susceptibility to aortic abdominal aneurysm in response to angiotensin II

(2018), Cardiovascular Research

Adipose Tissue-Derived Wnt5a as a Novel Link Between Obesity and Vascular Disease

Akoumianakis I. et al, (2018), CIRCULATION, 138

LOSS OF KIAA1462, A CORONARY ARTERY DISEASE ASSOCIATED GENE, DECREASES ATHEROSCLEROSIS

Douglas G. et al, (2018), CARDIOVASCULAR RESEARCH, 114, S3 - S3

Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control.

Patel J. et al, (2018), Vascul Pharmacol, 108, 15 - 22

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