Mechanisms of trastuzumab induced cardiotoxicity – is exercise a potential treatment?
Journal article
Eaton H. and Timm KN., (2023), Cardio-Oncology, 9
Neutrophils incite and macrophages avert electrical storm after myocardial infarction.
Journal article
Grune J. et al, (2022), Nat Cardiovasc Res, 1, 649 - 664
Hyperpolarised magnetic resonance spectroscopy of alpha-[1-C-13]-ketoisocaproic acid reveals reamination of branched chain ketoacids in H9c2 cardiomyocytes in the presence of ketone bodies but not L-glutamate, and this reamination is increased in the presence of the SGLT-2 inhibitor Empagliflozin
Conference paper
Kennedy BWC. et al, (2022), JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 173, S187 - S187
Probing hepatic metabolism of [2-13C]dihydroxyacetone in vivo with 1H-decoupled hyperpolarized 13C-MR.
Journal article
Marco-Rius I. et al, (2021), MAGMA, 34, 49 - 56
Hyperpolarized magnetic resonance shows that the antiischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved postischemic function in the diabetic heart
Journal article
SAVIC D. et al, (2021), NMR in Biomedicine
Early detection of doxorubicin-induced cardiotoxicity in rats by its cardiac metabolic signature assessed with hyperpolarized MRI
Journal article
Timm KN. et al, (2020), Communications Biology, 3
Rapid, $B_1$-insensitive, dual-band quasi-adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux
Journal article
Miller JJ. et al, (2020), Magnetic Resonance in Medicine
Nicotinic acid receptor agonists impair myocardial contractility by energy starvation.
Journal article
Watson WD. et al, (2020), FASEB J, 34, 14878 - 14891
A 3D hybrid-shot spiral sequence for hyperpolarized 13C imaging
Journal article
TYLER D. et al, (2020), Magnetic Resonance in Medicine
A 3D hybrid-shot spiral sequence for hyperpolarized 13C imaging
Journal article
TYLER D. et al, (2020), Magnetic Resonance in Medicine
Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol.
Journal article
Kerr M. et al, (2020), JCI Insight, 5
The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity.
Journal article
Timm KN. and Tyler DJ., (2020), Cardiovascular drugs and therapy
Investigating real-time metabolic flux changes in a rat model of doxorubicin-induced cardiotoxicity using hyperpolarized 13C magnetic resonance spectroscopy
Conference paper
Timm KN. et al, (2018), JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 120, 34 - 34
Novel dietary ketone ester lowers fasting blood glucose levels in Zucker diabetic fatty rats
Conference paper
Chong CR. et al, (2018), JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 120, 26 - 27
Assessing the optimal preparation strategy to minimize the variability of cardiac pyruvate dehydrogenase flux measurements with hyperpolarized MRS
Journal article
Timm KN. et al, (2018), NMR in Biomedicine
Cardiac applications of hyperpolarised magnetic resonance
Journal article
Timm KN. et al, (2018), Progress in Nuclear Magnetic Resonance Spectroscopy, 106-107, 66 - 87
Fatty acids prevent Hypoxia-Inducible Factor 1α signalling through decreased succinate in diabetes
Journal article
Heather L. et al, (2018), JACC: Basic to Translational Science
DEPLETION OF CARDIAC SUCCINATE MEDIATES IMPAIRED HYPOXIA-INDUCIBLE FACTOR 1A SIGNALLING BY LONG CHAIN FATTY ACIDS IN INSULIN RESISTANCE
Conference paper
Dodd MS. et al, (2018), HEART, 104, A11 - A11
EFFECTS OF CARNITINE SUPPLEMENTATION IN THE TYPE 1 DIABETIC HEART: AN IN VIVO HYPERPOLARIZED MRS STUDY
Conference paper
Savic D. et al, (2018), HEART, 104, A12 - A12
HYPERPOLARIZED 13C MAGNETIC RESONANCE SPECTROSCOPY IDENTIFIES CHANGES TO MYOCARDIAL METABOLIC FLUXES IN A RAT MODEL OF DOXORUBICIN-INDUCED CARDIOTOXICITY
Conference paper
Timm KN. et al, (2018), HEART, 104, A7 - A8