Brain aging shows nonlinear transitions, suggesting a midlife "critical window" for metabolic intervention.
Antal BB. et al, (2025), Proc Natl Acad Sci U S A, 122
Hyperpolarized 13C and 31P MRS detects differences in cardiac energetics, metabolism, and function in obesity, and responses following treatment.
Lewis AJM. et al, (2024), NMR Biomed, 37
The age-dependent development of abnormal cardiac metabolism in the peroxisome proliferator-activated receptor α-knockout mouse.
Dodd MS. et al, (2024), Atherosclerosis
On the interdependence of ketone body oxidation, glycogen content, glycolysis and energy metabolism in the heart.
Kadir AA. et al, (2023), J Physiol, 601, 1207 - 1224
The effects of endogenously- and exogenously-induced hyperketonemia on exercise performance and adaptation.
Dearlove DJ. et al, (2022), Physiol Rep, 10
Abnormal whole‑body energy metabolism in iron‑deficient humans despite preserved skeletal muscle oxidative phosphorylation
FRISE M. et al, (2021), Scientific Reports
β-Hydroxybutyrate Oxidation in Exercise Is Impaired by Low-Carbohydrate and High-Fat Availability
ROBERTSON J., (2021), Frontiers of Medicine
Exogenous d-β-hydroxybutyrate lowers blood glucose in part by decreasing the availability of L-alanine for gluconeogenesis.
Soto-Mota A. et al, (2021), Endocrinol Diabetes Metab
Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia.
Kerr M. et al, (2021), FASEB J, 35
Metabolic maturation of differentiating cardiosphere-derived cells.
Pakzad KK. et al, (2021), Stem Cell Res, 54
The Effect of Blood Ketone Concentration and Exercise Intensity on Exogenous Ketone Oxidation Rates in Athletes.
Dearlove DJ. et al, (2021), Med Sci Sports Exerc, 53, 505 - 516
Effects of acute nutritional ketosis during exercise in adults with glycogen storage disease type IIIa are phenotype-specific: An investigator-initiated, randomized, crossover study.
Hoogeveen IJ. et al, (2021), J Inherit Metab Dis, 44, 226 - 239
Exogenous ketosis in patients with type 2 diabetes: Safety, tolerability and effect on glycaemic control
Soto-Mota A. et al, (2021), Endocrinology, Diabetes and Metabolism
The Use of Reactive Oxygen Species Production by Succinate-Driven Reverse Electron Flow as an Index of Complex 1 Activity in Isolated Brown Adipose Tissue Mitochondria
Dlasková A. et al, (2021), Methods in Molecular Biology, 2310, 247 - 258
The ketone ester, 3-hydroxybutyl-3-hydroxybutyrate, attenuates neurobehavioral deficits and improves neuropathology following controlled cortical impact in male rats.
Almeida-Suhett C. et al, (2020), Nutr Neurosci, 1 - 13
Nicotinic acid receptor agonists impair myocardial contractility by energy starvation.
Watson WD. et al, (2020), FASEB J, 34, 14878 - 14891
Cardiac ketone body metabolism
Abdul Kadir A. et al, (2020), Biochimica et Biophysica Acta - Molecular Basis of Disease, 1866