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Lysosomal signalling pathways influence heart rhythm, and regulate atrial function
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Innovating cancer drug discovery with refined phenotypic screens
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Lysosomal signalling pathways influence heart rhythm, and regulate atrial function
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Protocol for separating cancer cell subpopulations by metabolic activity using flow cytometry
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Carnosine facilitates lysosomal release of inhibitors of T cell surveillance.
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Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid-resistance
MICHL J. et al, (2024), Proceedings of the National Academy of Sciences of the United States of America
Dynamic IL6R-STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells
BLASZCZAK W. et al, (2023), Cell Reports
What can we learn about acid-base transporters in cancer from studying somatic mutations in their genes?
White B. and Swietach P., (2023), Pflugers Arch
Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation
Park KC. et al, (2023), Nature Cardiovascular Research
Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter Anion Exchanger 2 (SLC4A2)
MICHL J. et al, (2023), Cell Reports
Permeability and driving force: why is difficult to control glycolytic flux by blocking lactate transporters?
Blaszczak W. and Swietach P., (2023), Oncotarget, 14, 51 - 52
Studying a propionic acidaemia mouse model reveals epigenetic mechanisms in the heart
Swietach P. and Park KC., (2023), NATURE CARDIOVASCULAR RESEARCH, 2, 1125 - 1126
Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes.
Monterisi S. et al, (2022), Elife, 11
Auto-regulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production
BLASZCZAK W. et al, (2022), British Journal of Cancer
Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells
Rabcuka J. et al, (2022), Blood Advances