How protons pave the way to aggressive cancers
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SWIETACH P. et al, (2023), Nature Reviews Cancer
Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter Anion Exchanger 2 (SLC4A2)
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Diffusion-limited O2release in human kidneys perfused with stored blood
Preprint
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Permeability and driving force: why is difficult to control glycolytic flux by blocking lactate transporters?
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Proton export upregulates aerobic glycolysis
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Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes.
Journal article
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Auto-regulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production
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Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells
Journal article
Rabcuka J. et al, (2022), Blood Advances
Elevated propionate signalling drives Pde9a overexpression and contractile dysfunction through increased histone acetylation and propionylation
Conference paper
Park KC. et al, (2022), CARDIOVASCULAR RESEARCH, 118
Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy
Journal article
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Optimal thinning of MCMC output
Journal article
SWIETACH P., (2022), Journal- Royal Statistical Society Series B
Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes
Preprint
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Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart
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CRISPR/Cas9 screen identifies oxidative phosphorylation as essential for cancer cell survival at low extracellular pH
Journal article
MICHL J. et al, (2022), Cell Reports
Acidic environments trigger intracellular H+-sensing FAK proteins to re-balance sarcolemmal acid-base transporters and auto-regulate cardiomyocyte pH
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What do cellular responses to acidity tell us about cancer?
Journal article
BLASZCZAK W. and SWIETACH P., (2021), Cancer and Metastasis Reviews
Stored blood has compromised oxygen unloading kinetics that can be normalized with rejuvenation and predicted from corpuscular side-scatter
Journal article
SWIETACH P. and DONOVAN K., (2021), Haematologica: the hematology journal
Cost-Effective Real-Time Metabolic Profiling of Cancer Cell Lines for Plate-Based Assays
Journal article
Blaszczak W. et al, (2021), CHEMOSENSORS, 9, 139 - 139
Sulphamate Derivatives of Maslinic Acid as a Therapeutic Option for human Breast Cancer
Conference paper
Petrenko M. et al, (2021), STRAHLENTHERAPIE UND ONKOLOGIE, 197, S131 - S132