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Publications

Early deficits in an in vitro striatal microcircuit model carrying the Parkinson's GBA-N370S mutation.

Do QB. et al, (2024), NPJ Parkinsons Dis, 10

Single-cell spatial transcriptomic and translatomic profiling of dopaminergic neurons in health, aging, and disease.

Kilfeather P. et al, (2024), Cell Rep, 43

Tau depletion in human neurons mitigates Aβ-driven toxicity.

Ng B. et al, (2024), Mol Psychiatry

Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons

WADE-MARTINS R., (2023), Molecular Neurodegeneration, 18

Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson’s

BRIMBLECOMBE K. et al, (2023), European Journal of Neuroscience

Patient-derived iPSC models of Friedreich ataxia: a new frontier for understanding disease mechanisms and therapeutic application

Maheshwari S. et al, (2023), Translational Neurodegeneration, 12

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9

Vahsen B. et al, (2023), Nature Communications

Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson's disease models.

Williamson MG. et al, (2023), Hum Mol Genet

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons

Beccano-Kelly DA. et al, (2023), iScience, 107044 - 107044

Impaired dopamine release in Parkinson’s disease

Cramb KML. et al, (2023), Brain

Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease GBA-N370S dopamine neurons

RYAN B., (2023), Cell Reports

Early striatal hyperexcitability in anin vitrohuman striatal microcircuit model carrying the Parkinson’sGBA-N370Smutation

Do Q. et al, (2023)

Identification of a possible proteomic Biomarker in Parkinson’s Disease: Discovery and Replication in Blood, brain and CSF

WINCHESTER L. and NEVADO-HOLGADO A., (2022), Brain Communications

Multiparameter phenotypic screening for endogenous TFEB and TFE3 translocation identifies novel chemical series modulating lysosome function.

Carling PJ. et al, (2022), Autophagy, 1 - 14

Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement.

Fdez E. et al, (2022), iScience, 25

Hyperexcitability in young iPSC-derived C9ORF72 mutant motor neurons is associated with increased intracellular calcium release.

Burley S. et al, (2022), Sci Rep, 12

Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability.

Ng B. et al, (2022), Brain Commun, 4

Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism.

Ng J. et al, (2021), Sci Transl Med, 13

REST protects dopaminergic neurons from mitochondrial and α-synuclein oligomer pathology in an alpha synuclein overexpressing BAC-transgenic mouse model.

Ryan BJ. et al, (2021), J Neurosci

Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer's disease.

Bengoa-Vergniory N. et al, (2021), Acta Neuropathol Commun, 9

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