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Publications

Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.

Ritzefeld M. et al, (2024), J Med Chem, 67, 1061 - 1078

Development of an inhibitor of the mutagenic SOS response that suppresses the evolution of quinolone antibiotic resistance

Bradbury JD. et al, (2024), Chemical Science

Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.

Jamshidiha M. et al, (2022), RSC medicinal chemistry, 13, 150 - 155

Evaluating Hedgehog Acyltransferase Activity and Inhibition Using the Acylation-coupled Lipophilic Induction of Polarization (Acyl-cLIP) Assay.

Andrei SA. et al, (2022), 2374, 13 - 26

Structure, mechanism, and inhibition of Hedgehog acyltransferase.

Coupland CE. et al, (2021), Mol Cell, 81, 5025 - 5038.e10

Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation.

Kallemeijn WW. et al, (2021), Nat Protoc, 16, 5083 - 5122

Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)**

Lanyon‐Hogg T. et al, (2021), Angewandte Chemie, 133, 13654 - 13659

Correction to "Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Antifibrotic Activity".

Panyain N. et al, (2020), Journal of the American Chemical Society, 142

Photochemical probe identification of the small-molecule binding site in a mammalian membrane-bound O-acyltransferase

Lanyon-Hogg T. et al, (2020)

Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Anti-Fibrotic Activity

Panyain N. et al, (2019)

Discovery of a Potent and Selective Covalent Inhibitor and Activity-Based Probe for the Deubiquitylating Enzyme UCHL1, with Anti-Fibrotic Activity

Panyain N. et al, (2019)

Include forthcoming?