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Zetaview Nanoparticle Tracking Analysis

  • ZetaView® is a Nanoparticle Tracking Analysis (NTA) instrument for measuring hydrodynamic particle size, zeta potential, concentration and fluorescence
  • Precision-engineered motorized scanning NTA instrument for tracking movement of individual visualized nanoparticles in suspension.
  • Real-time visualization of Brownian Motion and electrophoretic mobility, for measuring size, concentration and zeta potential in scatter and fluorescence mode (model dependent).
  • Fast scanning to acquire and analyze typically 2000 particles in less than 1 minute. Nanoparticles suspended in polar liquids (e.g. water, alcohols) for size, concentration, fluorescence and zeta potential studies.


Key Applications


Bionanoparticles:
Extracellular Vesicles (EVs)
Exosomes
Lipsomes & Micelles
Protein Agglomerates
Viruses & Virus-Like-Particles (VOPs)
Drug Delivery
Fluorescent-labelled NPs

Low Concentration Samples:
Nanobubbles
Nanometals
Trace Particles
Quantum Dots
Zetaview

Example Data

Zetaview example data

Adapted from Figure 7: Cardiovasc Res, cvac012, https://doi.org/10.1093/cvr/cvac012

Location

Level 5, West Wing,

John Radcliffe Hospital

Contact: Dr Naveed Akbar

Availability

Charge of £25 an hour (for servicing and calibration reagents)

Please provide filtered sterile phosphate buffered saline (PBS), 1 mL and 10 mL syringes and Eppendorf’s.

Training is required.

Publications

Rapid neutrophil mobilisation by VCAM-1+ endothelial extracellular vesicles.

Akbar N, Braithwaite AT, Corr EM, Koelwyn GJ, van Solingen C, Cochain C, Saliba AE, Corbin A, Pezzolla D, Møller Jørgensen M, Bæk R, Edgar L, De Villiers C, Gunadasa-Rohling M, Banerjee A, Paget D, Lee C, Hogg E, Costin A, Dhaliwal R, Johnson E, Krausgruber T, Riepsaame J, Melling GE, Shanmuganathan M; Oxford Acute Myocardial Infarction Study (OxAMI), Bock C, Carter DRF, Channon KM, Riley PR, Udalova IA, Moore KJ, Anthony D, Choudhury RP.Cardiovasc Res. 2022 Feb 4:cvac012. doi: 10.1093/cvr/cvac012. Online ahead of print.PMID: 3513485


Isolation and Characterization of Human Adipocyte-Derived Extracellular Vesicles using Filtration and Ultracentrifugation.

Akbar N, Pinnick KE, Paget D, Choudhury RP.J Vis Exp. 2021 Apr 19;(170). doi: 10.3791/61979.PMID: 33938882