Contact information
DPHIL SUPERVISOR PROFILE
Gillian Douglas
PhD
University Research Lecturer
Large studies linking common variations to the occurrence of coronary artery disease have enabled us to identify several new genes that may have a causative influence on the susceptibility to developing coronary artery disease. However, for many of these genes the mechanism by which they alter cardiovascular disease pathology is unknown.
Recent publications
-
Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition
Journal article
AKOUMIANAKIS I. et al, (2020), Science Translational Medicine
-
A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.
Journal article
Douglas G. et al, (2019), Cardiovasc Res
-
Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17//RAC1-mediated activation of NADPH oxidases
Journal article
AKOUMIANAKIS I. et al, (2019), Science Translational Medicine
-
Nox2 contributes to age-related oxidative damage to neurons and the cerebral vasculature.
Journal article
Fan LM. et al, (2019), J Clin Invest, 130
-
Deficiency in endothelial cell tetrahydrobiopterin increases resistance vascular remodelling, blood pressure, and susceptibility to aortic abdominal aneurysm in response to angiotensin II
Conference paper
(2018), Cardiovascular Research