DPHIL SUPERVISOR PROFILE
University Research Lecturer
Large studies linking common variations to the occurrence of coronary artery disease have enabled us to identify several new genes that may have a causative influence on the susceptibility to developing coronary artery disease. However, for many of these genes the mechanism by which they alter cardiovascular disease pathology is unknown.
Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition
AKOUMIANAKIS I. et al, (2020), Science Translational Medicine
A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.
Douglas G. et al, (2019), Cardiovasc Res
Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17//RAC1-mediated activation of NADPH oxidases
AKOUMIANAKIS I. et al, (2019), Science Translational Medicine
Nox2 contributes to age-related oxidative damage to neurons and the cerebral vasculature.
Fan LM. et al, (2019), J Clin Invest, 130
Deficiency in endothelial cell tetrahydrobiopterin increases resistance vascular remodelling, blood pressure, and susceptibility to aortic abdominal aneurysm in response to angiotensin II
(2018), Cardiovascular Research