Kieran Clarke
PhD
Emeritus Professor of Physiological Biochemistry
Since 1991, Professor Kieran Clarke has worked at the University of Oxford on the effects of diet on energy metabolism in human heart, brain and skeletal muscle. Specifically, her interest in physical and cognitive function has led to the development of a fourth food group, a ketone ester called ΔG®, that improves endurance exercise in athletes and could be used for the management of common metabolic diseases, such as type 2 diabetes.
Before Oxford, Professor Clarke worked as a postdoctoral fellow at Harvard University Medical School and as a research scientist at the NRC in Ottawa, Canada.
Key publications
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Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes
Journal article
Cox PJ. et al, (2016), Cell Metabolism, 24, 256 - 268
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Prior ingestion of exogenous ketone monoester attenuates the glycemic response to an oral glucose tolerance test in healthy young individuals
Journal article
Myette-Côté E. et al, (2018), The Journal of Physiology
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Novel ketone diet enhances physical and cognitive performance
Journal article
Cole MA. et al, (2016), The FASEB Journal
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On the Metabolism of Exogenous Ketones in Humans.
Journal article
Stubbs BJ. et al, (2017), Frontiers in physiology, 8, 848 - 848
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Ketone bodies mimic the life span extending properties of caloric restriction.
Journal article
Veech RL. et al, (2017), IUBMB Life, 69, 305 - 314
Recent publications
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Exogenous d-β-hydroxybutyrate lowers blood glucose in part by decreasing the availability of L-alanine for gluconeogenesis.
Journal article
Soto-Mota A. et al, (2021), Endocrinol Diabetes Metab