Contact information
Research groups
Thomas Lanyon-Hogg
Career Development Fellow
Research at the interface of chemistry, biology and drug discovery.
Medicinal Chemistry
As part of the Medicinal Chemistry Group in the Department of Pharmacology, my research involves the synthesis and development of biologically active small-molecules. This includes identification of new inhibitors by screening approaches, design of improved molecules using rational and computational guidance, and testing of molecules in biochemical, cellular and in vivo settings. Current Medicinal Chemistry projects include: development of molecules to reverse antibiotic resistance; development of inhibitors of the Hedgehog signalling pathway in cancer; identification of modulators of protease activity in cancer and development.
Chemical Biology
My research in Chemical Biology involves the use of chemical methodology and small molecules to probe biological questions. This encompasses a range of methodology including organic synthesis, biorthogonal 'click' chemistry, and biochemical or mass spectrometry-based proteomic analyses. Current areas of interest include: generation of novel platforms for modulation of protein-protein interactions; profiling of small-molecule targets in vivo.
Recent publications
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Identification of the first structurally validated covalent ligands of the small GTPase RAB27A.
Journal article
Jamshidiha M. et al, (2022), RSC medicinal chemistry, 13, 150 - 155
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Evaluating Hedgehog Acyltransferase Activity and Inhibition Using the Acylation-coupled Lipophilic Induction of Polarization (Acyl-cLIP) Assay.
Chapter
Andrei SA. et al, (2022), 2374, 13 - 26
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Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Journal article
Coupland CE. et al, (2021), Mol Cell, 81, 5025 - 5038.e10
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Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation.
Journal article
Kallemeijn WW. et al, (2021), Nat Protoc, 16, 5083 - 5122
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Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)**
Journal article
Lanyon‐Hogg T. et al, (2021), Angewandte Chemie, 133, 13654 - 13659