Oxford Cardiovascular Tissue BioResource
- 26 April 2011 to 25 April 2012
- Awards: Pump-priming Awards
The Oxford Cardiovascular Tissue BioResource was established by the Division of Cardiovascular Medicine in collaboration with the Nuffield Division of Clinical Laboratory Sciences, the Wellcome Trust Centre for Human Genetics, NHS Blood and Transplant and the Nuffield Department of Obstetrics. This bioresource systematically collected primary human umbilical cord vascular material (tissue, DNA, RNA) from mothers who delivered within the OUH NHS Trust and generated matched vascular cell subsets (endothelial cells, mesenchymal stem/stromal cells, vascular smooth muscle cells). Umbilical cords were sourced from both normal pregnancies and those with specific complications, such as preeclampsia or preterm delivery. This allows the resource to be used for both investigation of the role of pregnancy complications on later cardiovascular risk in both mother and offspring (clinical phenotype) as well as provide a cellular resource to investigate how novel genetic variants identified in genome wide association studies (genetic predisposition) impact on vascular cell function.
Publications linked to this award:
- Yu G, Aye C, Lewandowski AJ, Davis EF, K Cheen, Newton L, Cheng TY, Zen A, Simpson L, O'Brien K, Cook DA, Kyriakou T, Channon K, Watt S, Leeson P. Association of maternal anti-angiogenic profile at birth with early postnatal loss of microvascular density in offspring of hypertensive pregnancies. Hypertension. 2016 Sep;68(3):749-59
- Yu G, Leeson P. Hypertensive Pregnancy: A Cardiovascular Risk Marker for the Whole Family? Nat Rev Nephrol. 2017
- Yu, G., Reilly, S., Lewandowski, A., Aye, C., Simpson, L., Newton, L., Davis, E., Zhu, S., Fox, W., Goel, A., Watkins, H., Channon, K., Watt, S., Kyriakou, T. and Leeson, P. (2018). Neonatal MicroRNA Profile Determines Endothelial Function in Offspring of Hypertensive Pregnancies. Hypertension, 72(4), pp.937-945.