Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

An Oxford BHF CRE “Pump Priming” award to Professor Shoumo Bhattacharya and his research group led to a great return on investment with this exclusive licensing agreement for their innovative research.

© Shutterstock

Kyttaro Ltd, a UK biotechnology company, has entered into a world-wide license agreement with Oxford University Innovation (OUI) to develop and commercialize an anti-inflammatory peptide technology platform that is based on naturally occurring proteins derived from ticks, viruses and other organisms that have evolved over millennia to target and inhibit key components of the human immune system.

This research work was led by Professor Shoumo Bhattacharya, and the platform technology was developed with funding received from the British Heart Foundation. The platform has the potential to treat a wide range of inflammatory conditions across multiple therapeutic areas including cardiovascular disease.

Atherosclerotic cardiovascular disease (ASCVD), such as coronary artery disease (CAD), are a leading cause of morbidity and mortality worldwide despite extensive use of existing ASCVD therapies (e.g. statins). It is estimated that CAD, which involves plaque formation in the blood vessels supplying the heart, is the most common heart disease in the US with 20M affected individuals and that CAD was responsible for c.360k US deaths in 2019.  Inflammation has been identified as a key risk factor in ASCVD that promotes disease progression and is associated with ASCVD-related complication. Emerging evidence from clinical studies showed that reducing inflammation on top of standard therapy has a clinical benefit and reduces cardiovascular events. 

Professor Shoumo Bhattacharya, Inventor of the technology and PI at the Radcliffe Department of Medicine, University of Oxford, stated: “I am looking forward to collaborating with the team at Kyttaro to accelerate the development of the anti-inflammatory platform technology that is based on naturally occurring proteins that have evolved in parasites for millions of years to circumvent the human’s body immune response. This technology offers hugely promising treatment options for inflammatory conditions including cardiovascular disease.”

Find out more. 

Similar stories

BHF Senior Fellowship renewal for Duncan Sparrow could pave the way to revealing unknown causes of heart defects in babies

Congratulations are in order for Associate Professor Duncan Sparrow, who has been awarded a renewal of his British Heart Foundation Senior Basic Science Research Fellowship. The award will fund crucial investigations into little understood environmental risk factors of congenital heart disease, and could one day lead to new therapeutic strategies.

Joaquim Vieira brings heart regeneration research to the public at Pint of Science

Pint of Science is the world’s largest public science festival bringing researchers to local pubs, cafes and spaces to share their scientific discoveries with the public.

DPAG researchers showcased at premier European Society of Cardiology meeting

DPAG scientists across four research groups were highlighted at the major annual European Society of Cardiology basic science conference (FCVB 2022). Congratulations are in order for Dr KC Park on receiving the Young Investigator Award and to Dr Elisabetta Gamen on winning the Moderated Poster Prize.

The effect of nuclear pH on cardiac gene expression

Research led by Dr Alzbeta Hulikova and Professor Pawel Swietach has, for the first time, described the potential regulation of nuclear acid-base chemistry in neonatal and adult cardiomyocytes, and explained its relevance in the context of heart physiology and pathology.

RDM researchers awarded £2million MRC grant

Researchers at the Cardiovascular Clinical Research Facility (CCRF) have won a five year MRC funding programme to help understand how high blood pressure (hypertension) during pregnancy affects the heart, brain and blood vessels throughout the life of women, as well as the children born after such a pregnancy.

Study indicates reasons for decline in death rates from heart attacks

A new study involving Oxford Population Health researchers finds that both prevention and improved treatments have helped reduce deaths from heart attacks - but the relative importance of each varies by country, age and sex.