Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Research carried out by the Department of Physiology, Anatomy & Genetics represents advances in vascular development knowledge.

A new study published in Nature Communications highlights a major and previously unsuspected role for Bone Morphogenetic Proteins in the acquisition and maintenance of vein identity, through a detailed analysis of early vascular patterning in mice and zebrafish. BMPs are a group of growth factors originally discovered by their ability to induce the formation of bone and cartilage.

Lead Researcher Sarah De Val said "This work places BMP signalling at the top of a regulatory cascade that activates venous identity. It represents a fundamental advance in both our knowledge of vascular development and our understanding of the role of the BMP pathway. It also provides a wealth of novel targets for therapeutic manipulations of vascular growth, for example in heart disease and cancer." 

Read more (Department of Physiology, Anatomy & Genetics website)

 

 

Similar stories

Study develops radiotranscriptomic AI analysis to enable virtual heart biopsies

RDM researchers tested the method in COVID-19 patients, to find that the results predicted in-hospital mortality.

BHF Senior Fellowship renewal for Duncan Sparrow could pave the way to revealing unknown causes of heart defects in babies

Congratulations are in order for Associate Professor Duncan Sparrow, who has been awarded a renewal of his British Heart Foundation Senior Basic Science Research Fellowship. The award will fund crucial investigations into little understood environmental risk factors of congenital heart disease, and could one day lead to new therapeutic strategies.

The effect of nuclear pH on cardiac gene expression

Research led by Dr Alzbeta Hulikova and Professor Pawel Swietach has, for the first time, described the potential regulation of nuclear acid-base chemistry in neonatal and adult cardiomyocytes, and explained its relevance in the context of heart physiology and pathology.

Study indicates reasons for decline in death rates from heart attacks

A new study involving Oxford Population Health researchers finds that both prevention and improved treatments have helped reduce deaths from heart attacks - but the relative importance of each varies by country, age and sex.

Review highlights impact of Long COVID on cardiovascular system

The wide-ranging effects of Long COVID and the associated issues for healthcare providers have been revealed in a new review of the major studies into the condition, which specifically highlights the impact of Long COVID on the cardiovascular system.