Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A new discovery on how iron deficiency affects the vasculature of the lung could hold the key to improving treatment of pulmonary arterial hypertension.

A new paper from the Lakhal-Littleton Group at Oxford’s Department of Physiology Anatomy & Genetics describes the way in which iron deficiency affects human vasculature - in particular the vasculature of the lung.

Iron deficiency is the most common nutritional disorder in the word. Its prevalence is particularly high in patients with cardiovascular diseases, in whom it is associated with poor outcome.

It has been known for some time that iron deficiency predisposes to pulmonary arterial hypertension (PAH). In this condition, the vasculature in the lungs is constricted and remodelled, and this puts pressure on the right side of the heart. For some time it was thought that PAH is caused by anaemia, a condition in which iron deficiency is the underlying mechanism. Consequently, the only consideration given to iron deficiency in the clinical setting has been in the context of correcting anaemia.

Read more (University of Oxford website)

Read more and watch an interview with Associate Professor Lakhal-Littleton (Department of Physiology, Anatomy & Genetics website)

Similar stories

Study develops radiotranscriptomic AI analysis to enable virtual heart biopsies

RDM researchers tested the method in COVID-19 patients, to find that the results predicted in-hospital mortality.

BHF Senior Fellowship renewal for Duncan Sparrow could pave the way to revealing unknown causes of heart defects in babies

Congratulations are in order for Associate Professor Duncan Sparrow, who has been awarded a renewal of his British Heart Foundation Senior Basic Science Research Fellowship. The award will fund crucial investigations into little understood environmental risk factors of congenital heart disease, and could one day lead to new therapeutic strategies.

The effect of nuclear pH on cardiac gene expression

Research led by Dr Alzbeta Hulikova and Professor Pawel Swietach has, for the first time, described the potential regulation of nuclear acid-base chemistry in neonatal and adult cardiomyocytes, and explained its relevance in the context of heart physiology and pathology.

Study indicates reasons for decline in death rates from heart attacks

A new study involving Oxford Population Health researchers finds that both prevention and improved treatments have helped reduce deaths from heart attacks - but the relative importance of each varies by country, age and sex.

Review highlights impact of Long COVID on cardiovascular system

The wide-ranging effects of Long COVID and the associated issues for healthcare providers have been revealed in a new review of the major studies into the condition, which specifically highlights the impact of Long COVID on the cardiovascular system.