Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A new discovery on how iron deficiency affects the vasculature of the lung could hold the key to improving treatment of pulmonary arterial hypertension.

A new paper from the Lakhal-Littleton Group at Oxford’s Department of Physiology Anatomy & Genetics describes the way in which iron deficiency affects human vasculature - in particular the vasculature of the lung.

Iron deficiency is the most common nutritional disorder in the word. Its prevalence is particularly high in patients with cardiovascular diseases, in whom it is associated with poor outcome.

It has been known for some time that iron deficiency predisposes to pulmonary arterial hypertension (PAH). In this condition, the vasculature in the lungs is constricted and remodelled, and this puts pressure on the right side of the heart. For some time it was thought that PAH is caused by anaemia, a condition in which iron deficiency is the underlying mechanism. Consequently, the only consideration given to iron deficiency in the clinical setting has been in the context of correcting anaemia.

Read more (University of Oxford website)

Read more and watch an interview with Associate Professor Lakhal-Littleton (Department of Physiology, Anatomy & Genetics website)

Similar stories

Drug could help diabetic hearts recover after a heart attack

New research led by Associate Professor Lisa Heather has found that a drug known as molidustat, currently in clinical trials for another condition, could reduce risk of heart failure after heart attacks.

Richard Tyser and Jack Miller honoured by the British Society of Cardiovascular Research

Dr Richard Tyser is this year’s winner of the Bernard and Joan Marshall Early Career Investigator Prize, and Dr Jack Miller has received a runner-up award, at the British Society of Cardiovascular Research Autumn Meeting.

Xin Sun shortlisted in national science image competition

DPAG Postdoctoral Research Scientist Dr Xin Sun has been shortlisted in the British Heart Foundation’s (BHF) annual ‘Reflections of Research’ image competition.

Reducing fat in the diabetic heart could improve recovery from heart attack

New research from the Heather Group has shown that in type 2 diabetes an overload of lipids reduces the heart’s ability to generate energy during a heart attack, decreasing chances of recovery.

Critical six-week window to ‘reset’ blood pressure after giving birth

Home blood pressure monitors could help mothers significantly lower high blood pressure after pregnancy