Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Researchers at the Nuffield Department of Population Health, in collaboration with other researchers, have published new findings that identify a combination of factors that put some patients at higher risk of myopathy.

Drugs in blister packaging © Shutterstock

Statins are prescribed to millions of people worldwide to reduce their risks of suffering heart attacks and strokes. Researchers at the Nuffield Department of Population Health, in collaboration with other researchers, have published new findings that identify a combination of factors that put some patients at higher risk of myopathy, which is a rare side-effect of statin therapy characterised by muscle pain or weakness in combination with high blood levels of creatine kinase, a marker of muscle damage.

The research, which is published today in The European Heart Journal, used data from nearly 60,000 individuals at high risk of heart attacks and strokes collected systematically during three large-scale clinical trials conducted over the last 25 years. This study analysed information on myopathy cases and reports of other muscle symptoms in patients who had been treated for an average of 3.4 years with simvastatin, one of the most commonly prescribed statins worldwide.

Read the full article (Nuffield Department of Population Health website)

Similar stories

BHF Senior Fellowship renewal for Duncan Sparrow could pave the way to revealing unknown causes of heart defects in babies

Congratulations are in order for Associate Professor Duncan Sparrow, who has been awarded a renewal of his British Heart Foundation Senior Basic Science Research Fellowship. The award will fund crucial investigations into little understood environmental risk factors of congenital heart disease, and could one day lead to new therapeutic strategies.

Joaquim Vieira brings heart regeneration research to the public at Pint of Science

Pint of Science is the world’s largest public science festival bringing researchers to local pubs, cafes and spaces to share their scientific discoveries with the public.

DPAG researchers showcased at premier European Society of Cardiology meeting

DPAG scientists across four research groups were highlighted at the major annual European Society of Cardiology basic science conference (FCVB 2022). Congratulations are in order for Dr KC Park on receiving the Young Investigator Award and to Dr Elisabetta Gamen on winning the Moderated Poster Prize.

The effect of nuclear pH on cardiac gene expression

Research led by Dr Alzbeta Hulikova and Professor Pawel Swietach has, for the first time, described the potential regulation of nuclear acid-base chemistry in neonatal and adult cardiomyocytes, and explained its relevance in the context of heart physiology and pathology.

RDM researchers awarded £2million MRC grant

Researchers at the Cardiovascular Clinical Research Facility (CCRF) have won a five year MRC funding programme to help understand how high blood pressure (hypertension) during pregnancy affects the heart, brain and blood vessels throughout the life of women, as well as the children born after such a pregnancy.

Study indicates reasons for decline in death rates from heart attacks

A new study involving Oxford Population Health researchers finds that both prevention and improved treatments have helped reduce deaths from heart attacks - but the relative importance of each varies by country, age and sex.