Professor Samira Lakhal-Littleton authors article on iron deficiency and supplementation in heart failure for Nature Reviews Cardiology

In the past decade, the Lakhal-Littleton team have uncovered the mechanisms and importance of iron regulation in different cells within the cardiovascular system^1-5 . More recently, their discoveries have challenged accepted notions about how the heart handles iron from intravenous iron therapy in patients⁶. The current review harnesses this growing understanding to dissect, at a more mechanistic level, the adverse impact of iron deficiency in heart failure patients, and the mixed success of iron supplementation therapies in this context⁷. It also highlights untapped opportunities for improving the management of iron deficiency in heart failure.

1. DOI: 10.1161/ATVBAHA.123.319224
2. DOI: 10.3389/fcvm.2020.616920
3. DOI: 10.1073/pnas.1822010116
4. DOI: 10.1073/pnas.1422373112
5. DOI: 10.7554/eLife.19804
6.  https://doi.org/10.1101/2024.01.18.24301496
7. DOI: 10.1038/s41569-024-00988-1  (fulltext available on https://rdcu.be/dx5vu)

Read more about the research being done by the Lakhal-Littleton group here.

Read the full article at https://rdcu.be/dx5vu