Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Magnetic resonance elastography (MRE) is a noninvasive method of measuring tissue compliance. Current MRE methods rely on custom-built hardware to elicit vibrations that are tracked by MR imaging. Knowledge of the wave propagation can be used to calculate the local shear stiffness of the tissue. We sought to determine whether the vibrations of the patient table that result from low-frequency switching of the imaging gradients could be used as an alternative mechanical driving mechanism for MRE. We designed a pulse sequence that includes a gradient lobe specifically for the excitation of mechanical resonance, allowing control of the time between the onset of the vibrations and the velocity-encoding of the readout. Data collected from a gelatin phantom with stiff cylindrical gelatin inserts demonstrated that wave propagation can be imaged with this method. Postprocessing to estimate the local spatial frequency of the waves also allows estimation of the local shear stiffness, where the stiff inserts are clearly identifiable. Data collected on the brain of a normal healthy volunteer showed clear rotational waves propagating from the skull inwards, also allowing generation of shear stiffness maps.

Original publication




Journal article


Magn Reson Med

Publication Date





815 - 821


Beds, Brain, Elasticity Imaging Techniques, Humans, Image Enhancement, Reproducibility of Results, Sensitivity and Specificity