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Parasympathetic control of heart rate involves the exocytotic release of acetylcholine and muscarinic receptor regulation of pacemaking currents. Endogenous nitric oxide can potentially regulate all of these processes; however, recent work suggests that the main functional role of nitric oxide lies in the modulation of acetylcholine release.


Journal article


News Physiol Sci

Publication Date





202 - 206


Animals, Biological Clocks, Heart Rate, Humans, Nitric Oxide, Nitric Oxide Synthase, Nitric Oxide Synthase Type III, Parasympathetic Nervous System