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Mitochondrial Ca(2+) uptake shapes the profile of intracellular Ca(2+) signals, both spatially and temporally. In addition, such uptake controls the gating of Ca(2+) release and store-operated Ca(2+) entry channels, partitions cells into subcellular Ca(2+) hotspots, and can result in the release of diffusible signals into the cytosol that subsequently regulate protein function.


Journal article


News Physiol Sci

Publication Date





252 - 256


Animals, Buffers, Calcium, Calcium Signaling, Intracellular Membranes, Mitochondria