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Muscle degeneration in the heart of 1-9 month-old mdx mice (a model for Duchenne muscular dystrophy) has been monitored using metabolomic and proteomic approaches. In both data sets, a pronounced aging trend was detected in control and mdx mice, and this trend was separate from the disease process. In addition, the characteristic increase in taurine associated with dystrophic tissue is correlated with proteins associated with oxidative phosphorylation and mitochondrial metabolism.

Original publication




Journal article


J Proteome Res

Publication Date





2069 - 2077


Aging, Animals, Dystrophin, Male, Metabolism, Mice, Mice, Inbred C57BL, Mice, Inbred mdx, Muscular Dystrophy, Duchenne, Myocardium, Nuclear Magnetic Resonance, Biomolecular, Pattern Recognition, Automated, Proteome, Proteomics, Taurine