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Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, rg = 0.11, P = 3.56 × 10-06) and systolic BP (SBP, rg = 0.06, P = 0.01), but not pulse pressure (PP, rg = -0.01, P = 0.75). Cross-trait meta-analysis reveals 14 shared loci (P ≤ 5 × 10-08), nine of which replicate (P 

Original publication




Journal article


Nat Commun

Publication Date





Blood Pressure, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Hypertension, Integrin beta Chains, Mendelian Randomization Analysis, Meta-Analysis as Topic, Migraine Disorders, Polymorphism, Single Nucleotide, Proteins, Receptors, Adrenergic, alpha-2, Risk Factors, Telomerase