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PURPOSE: To assess the potential of a gene reporter system, based on a urea transporter (UTB) and hyperpolarized [(13) C]urea. METHODS: Mice were implanted subcutaneously with either unmodified control cells or otherwise identical cells expressing UTB. After injection of hyperpolarized [(13) C]urea, a spin echo sequence was used to measure urea concentration, T1 , and diffusion in control and UTB-expressing tissue. RESULTS: The apparent diffusion coefficient of hyperpolarized urea was 21% lower in tissue expressing UTB, in comparison with control tissue (P 

Original publication




Journal article


Magn Reson Med

Publication Date





1401 - 1406


13C MRS, gene reporter, hyperpolarization, urea transporter, Animals, Carbon Isotopes, HEK293 Cells, Humans, Magnetic Resonance Spectroscopy, Membrane Transport Proteins, Mice, Mice, SCID, Reproducibility of Results, Sensitivity and Specificity, Tissue Distribution, Transgenes, Urea