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Introduction. In 1980 Furchgort and Zawadzki [1] showed that the vascular endothelium is capable of releasing a potent short-acting vasodilating substance in response to the application of acetylcholine (ACh). This substance, initially defined as endothelium-derived relaxing factor, was subsequently identified with nitric oxide (NO) [2]. Since then a wealth of research has demonstrated the involvement of this molecule not only in the regulation of vascular resistance but also in immunological processes, neuronal transmission, platelet function, growth of smooth muscle cells and cardiac mechanical and electrophysiological properties [3-5].

Type

Journal article

Journal

Blood Press Monit

Publication Date

06/1997

Volume

2

Pages

125 - 131