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Cyclic ADP-ribose (cADPR), an endogenous NAD+ metabolite in many mammalian and invertebrate tissues, is a potent mediator of calcium mobilization in sea urchin eggs. Our results show that cADPR also stimulates calcium release from rat brain microsomes, marked release occurring over the concentration range 10-250 nM. This is not inhibited by concentrations of heparin which completely abolish inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release. Ryanodine (100 microM) inhibits the cADPR response. Our results are consistent with cADPR being an endogenous messenger mediating Ca2+ release from ryanodine-sensitive pools in brain.

Original publication




Journal article


FEBS letters

Publication Date





259 - 263


Department of Pharmacology, University of Oxford, UK.


Brain, Microsomes, Animals, Rats, Rats, Wistar, Calcium, Inositol 1,4,5-Trisphosphate, Ryanodine, Adenosine Diphosphate Ribose, Cyclic ADP-Ribose, Heparin, Male, Hot Temperature