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Protein assemblies are critical for cellular function and understanding their physical organization is the key aim of structural biology. However, applying conventional structural biology approaches is challenging for transient, dynamic, or polydisperse assemblies. There is therefore a growing demand for hybrid technologies that are able to complement classical structural biology methods and thereby broaden our arsenal for the study of these important complexes. Exciting new developments in the field of mass spectrometry and proteomics have added a new dimension to the study of protein-protein interactions and protein complex architecture. In this review, we focus on how complementary mass spectrometry-based techniques can greatly facilitate structural understanding of protein assemblies.

Original publication

DOI

10.1074/mcp.R111.014027

Type

Journal article

Journal

Mol Cell Proteomics

Publication Date

03/2012

Volume

11

Keywords

Humans, Mass Spectrometry, Protein Interaction Mapping, Proteins, Proteomics