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Spontaneous shrinking: the intrinsically disordered tumor suppressor protein p53 was analyzed by using a combination of ion mobility mass spectrometry and molecular dynamics simulations. Structured p53 subdomains retain their overall topology upon transfer into the gas phase. When intrinsically disordered segments are introduced into the protein sequence, however, the complex spontaneously collapses in the gas phase to a compact conformation.

Original publication

DOI

10.1002/anie.201203047

Type

Journal article

Journal

Angew Chem Int Ed Engl

Publication Date

02/01/2013

Volume

52

Pages

361 - 365

Keywords

Gases, Humans, Mass Spectrometry, Models, Molecular, Molecular Dynamics Simulation, Protein Folding, Tumor Suppressor Protein p53