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The introduction of 5-HT3 antagonists, such as ondansetron, as antiemetic agents has transformed the management of patients receiving chemotherapy or radiation therapy. Studies in animal models with NK1 antagonists suggest that these represent a new class of antiemetic agents having a broader spectrum of activity than 5-HT3 antagonists. Compounds of this class may prove to be more effective in man against delayed emesis induced by cisplatin, post-operative nausea and vomiting and motion sickness. Thus, they have the potential to complement 5-HT3 antagonists and so provide a further advance in the management of nausea and vomiting.

Original publication

DOI

10.1159/000227649

Type

Journal article

Journal

Oncology

Publication Date

06/1996

Volume

53 Suppl 1

Pages

102 - 109

Keywords

Animals, Antiemetics, Forecasting, Humans, Neurokinin-1 Receptor Antagonists, Reflex, Vomiting