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Electrospray mass spectrometry has been used to investigate the mechanism of inhibition of class A and C β-lactamases by 6-halogenopenicillanic acids; in the case of the 6β-halogen substituted penicillanic acids the molecular mass differences observed between the unreacted and the inhibited β-lactamases are consistent with the formation of an enzyme bound dihydrothiazine derivative, as previously proposed.

Original publication




Journal article


Journal of the Chemical Society, Chemical Communications

Publication Date



121 - 123