Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

This review describes the effects of changes in left ventricular pressures and heart rate on myocardial high-energy phosphate metabolism. When cardiac workload is substantially increased, creatine kinase flux will increase markedly, phosphocreatine will show a small but detectable decrease, and ATP will not change. In this context, heart rate is a much weaker acute metabolic stimulus than left ventricular developed pressure. However, in heart failure, chronic reduction of heart rate has beneficial effects on alterations of high-energy phosphate metabolism.


Journal article


Basic Res Cardiol

Publication Date



93 Suppl 1


102 - 107


Adenosine Triphosphate, Animals, Energy Metabolism, Heart Rate, Humans, Myocardium, Oxygen Consumption, Phosphocreatine, Ventricular Function, Left