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The lasso peptide microcin J25 is known to hijack the siderophore receptor FhuA for initiating internalization. Here, we provide what is to our knowledge the first structural evidence on the recognition mechanism, and our biochemical data show that another closely related lasso peptide cannot interact with FhuA. Our work provides an explanation on the narrow activity spectrum of lasso peptides and opens the path to the development of new antibacterials.

Original publication

DOI

10.1038/nchembio.1499

Type

Journal article

Journal

Nat Chem Biol

Publication Date

05/2014

Volume

10

Pages

340 - 342

Keywords

Anti-Infective Agents, Bacterial Outer Membrane Proteins, Bacteriocins, Endocytosis, Escherichia coli, Escherichia coli Proteins, Models, Molecular, Protein Conformation, Receptors, Cell Surface