Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

We compared fine-scale recombination rates at orthologous loci in humans and chimpanzees by analyzing polymorphism data in both species. Strong statistical evidence for hotspots of recombination was obtained in both species. Despite approximately 99% identity at the level of DNA sequence, however, recombination hotspots were found rarely (if at all) at the same positions in the two species, and no correlation was observed in estimates of fine-scale recombination rates. Thus, local patterns of recombination rate have evolved rapidly, in a manner disproportionate to the change in DNA sequence.

Original publication




Journal article



Publication Date





107 - 111


Alleles, Animals, Base Sequence, Chromosome Mapping, Chromosomes, Human, Chromosomes, Mammalian, Evolution, Molecular, Genome, Genome, Human, Genotype, Globins, HLA Antigens, Haplotypes, Humans, Linkage Disequilibrium, Markov Chains, Monte Carlo Method, Pan troglodytes, Polymorphism, Single Nucleotide, Recombination, Genetic, Sequence Homology, Nucleic Acid