Building a roadmap for developing combination therapies for Alzheimer's disease.
Perry D., Sperling R., Katz R., Berry D., Dilts D., Hanna D., Salloway S., Trojanowski JQ., Bountra C., Krams M., Luthman J., Potkin S., Gribkoff V., Temple R., Wang Y., Carrillo MC., Stephenson D., Snyder H., Liu E., Ware T., McKew J., Fields FO., Bain LJ., Bens C.
Combination therapy has proven to be an effective strategy for treating many of the world's most intractable diseases. A growing number of investigators in academia, industry, regulatory agencies, foundations and advocacy organizations are interested in pursuing a combination approach to treating Alzheimer's disease. A meeting co-hosted by the Accelerate Cure/Treatments for Alzheimer's Disease Coalition, the Critical Path Institute and the Alzheimer's Association addressed challenges in designing clinical trials to test multiple treatments in combination and outlined a roadmap for making such trials a reality.