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Endothelial cells, which are located at the interface between the blood and the vessel wall, respond dynamically to a variety of stimuli initiating signaling cascades that regulate cardiovascular development, physiology and pathology. These inputs include soluble factors that bind to their receptors, integrin-matrix interactions, cell-cell contacts and mechanical forces due to the flowing blood. While these stimuli can mediate unique downstream signals, it is well-accepted that signaling pathways are highly interwoven into complex signaling networks with several levels of cross-talk, integration and coordination. Recent studies suggest that several signaling networks coalesce at the adaptor protein Shc.

Original publication




Journal article


Cell Cycle

Publication Date





231 - 235


Animals, Cell Adhesion, Cell-Matrix Junctions, Humans, Models, Biological, Protein-Tyrosine Kinases, Shc Signaling Adaptor Proteins, Signal Transduction