Sensitivity analysis of diffusion tensor MRI in simulated rat myocardium
Bates J., Teh I., Kohl P., Schneider JE., Grau V.
© Springer International Publishing Switzerland 2015. A model of cardiac microstructure and diffusion MRI is presented. The results show a good correspondence between the simulated and experimental measurements. A sensitivity analysis shows that the diffusivity has the greatest effect on both the apparent diffusion coefficient and the fractional anisotropy. The cross-sectional area of the cells is the next most important factor; the aspect ratio of the cell cross-section also affects the fractional anisotropy. Neither the cell length nor the volume fraction of cells has a marked effect.