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The minutiae of subtle changes that occur in response to ligand binding in multiprotein complexes are often difficult to assess without resource to high resolution X-ray analysis. Recent developments in mass spectrometry, however, are providing insight into dynamic changes within components. In this article we review recent applications of MS for selection of ligands and definition of their binding characteristics for individual protein targets through to macromolecular complexes such as ribosomes.

Original publication

DOI

10.1016/j.cbpa.2003.11.005

Type

Journal article

Journal

Curr Opin Chem Biol

Publication Date

02/2004

Volume

8

Pages

60 - 65

Keywords

Humans, Ligands, Lipid Metabolism, Lipids, Mass Spectrometry, Nucleic Acids, Peptide Library, Protein Binding, Proteins