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Mass spectrometry has become increasingly important in amyloid research specifically in the mechanism of formation and characterization of fibrils. In this review we highlight key experiments that provide evidence for different conformations, interactions and unfolding intermediates in proteins associated with amyloid diseases.

Type

Journal article

Journal

Protein Pept Lett

Publication Date

2006

Volume

13

Pages

255 - 260

Keywords

Amyloid, Kinetics, Mass Spectrometry, Protein Conformation, Spectrometry, Mass, Electrospray Ionization