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It is now well established that protein complexes can be maintained in the gas phase, under the reduced pressure conditions experienced within mass spectrometers. This remains an intriguing phenomenon, given the importance placed on water molecules in stabilizing protein structure. As a consequence, the overall structure of protein molecules and their complexes in the gas phase continues to stimulate much research. The eventual outcomes of this research will not only increase the number of applications of mass spectrometry to structural biology, but will also enhance our understanding of the interactions important for maintaining protein complexes in the absence of bulk solvent.

Original publication

DOI

10.1016/j.cbpa.2006.08.020

Type

Journal article

Journal

Curr Opin Chem Biol

Publication Date

10/2006

Volume

10

Pages

402 - 408

Keywords

Mass Spectrometry, Protein Conformation, Protein Structure, Quaternary, Proteins, Sensitivity and Specificity, Vacuum, Water