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Adipose tissue (AT) has recently been identified as a dynamic endocrine organ secreting a wide range of adipokines. Adiponectin is one such hormone, exerting endocrine and paracrine effects on the cardiovascular system. At a cellular and molecular level, adiponectin has anti-inflammatory, anti-oxidant and anti-apoptotic roles, thereby mitigating key mechanisms underlying cardiovascular disease (CVD) pathogenesis. However, adiponectin expression in the human AT as well as its circulating levels are increased in advanced CVD states, and it is actually considered by many as a "rescue hormone". Due to the complex mechanisms regulating adiponectin's biosynthesis in the human AT, measurement of its levels as a biomarker in CVD is highly controversial, given that it exerts protective effects on the cardiovascular system but at the same time its increased levels flag advanced CVD. In this review article we present the role of adiponectin in CVD pathogenesis and we discuss its role as a clinical biomarker.

Type

Journal article

Journal

British journal of pharmacology

Publication Date

15/09/2016

Addresses

Cardiovascular Medicine Division, Radcliffe Department of Medicine, University of Oxford, UK.