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CMR T1 mapping is a quantitative imaging technique allowing the assessment of myocardial injury early after ST-segment-elevation myocardial infarction. We sought to investigate the ability of acute native T1 mapping to differentiate reversible and irreversible myocardial injury and its predictive value for left ventricular remodeling.Sixty ST-segment-elevation myocardial infarction patients underwent acute and 6-month 3T CMR, including cine, T2-weighted (T2W) imaging, native shortened modified look-locker inversion recovery T1 mapping, rest first pass perfusion, and late gadolinium enhancement. T1 cutoff values for oedematous versus necrotic myocardium were identified as 1251 ms and 1400 ms, respectively, with prediction accuracy of 96.7% (95% confidence interval, 82.8% to 99.9%). Using the proposed threshold of 1400 ms, the volume of irreversibly damaged tissue was in good agreement with the 6-month late gadolinium enhancement volume (r=0.99) and correlated strongly with the log area under the curve troponin (r=0.80) and strongly with 6-month ejection fraction (r=-0.73). Acute T1 values were a strong predictor of 6-month wall thickening compared with late gadolinium enhancement.Acute native shortened modified look-locker inversion recovery T1 mapping differentiates reversible and irreversible myocardial injury, and it is a strong predictor of left ventricular remodeling in ST-segment-elevation myocardial infarction. A single CMR acquisition of native T1 mapping could potentially represent a fast, safe, and accurate method for early stratification of acute patients in need of more aggressive treatment. Further confirmatory studies will be needed.

Original publication




Journal article


Circulation. Cardiovascular imaging

Publication Date





From the Division of Cardiovascular Medicine, Radcliffe Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, United Kingdom (D.L., A.B., D.V., M.A., G.L.D.M., G.F., S.D., R.W., J.F., V.F., S.P., M.D.R., R.C., S.N., E.D.A.); Department of Cardiovascular Medicine, Oxford Heart Centre, John Radcliffe Hospital, Headley Way, United Kingdom (A.B., K.C., R.K.); and Department of Radiology, Brigham and Women's Hospital, Boston, MA (M.J.-H.).


Myocardium, Humans, Edema, Cardiac, Necrosis, Troponin I, Contrast Media, Diagnosis, Differential, Magnetic Resonance Imaging, Cine, Stroke Volume, Treatment Outcome, Area Under Curve, Prospective Studies, Reproducibility of Results, Predictive Value of Tests, ROC Curve, Recovery of Function, Ventricular Function, Left, Ventricular Remodeling, Time Factors, Aged, Middle Aged, England, Female, Male, Percutaneous Coronary Intervention, Biomarkers, ST Elevation Myocardial Infarction