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In this paper, we present a novel approach to quantify the spatio-temporal organization of electrical activation during human ventricular fibrillation (VF). We propose three different methods based on correlation analysis, graph theoretical measures and hierarchical clustering. Using the proposed approach, we quantified the level of spatio-temporal organization during three episodes of VF in ten patients, recorded using multi-electrode epicardial recordings with 30 s coronary perfusion, 150 s global myocardial ischaemia and 30 s reflow. Our findings show a steady decline in spatio-temporal organization from the onset of VF with coronary perfusion. We observed transient increases in spatio-temporal organization during global myocardial ischaemia. However, the decline in spatio-temporal organization continued during reflow. Our results were consistent across all patients, and were consistent with the numbers of phase singularities. Our findings show that the complex spatio-temporal patterns can be studied using complex network analysis.

Original publication




Journal article


Ann Biomed Eng

Publication Date





864 - 876


Complex network analysis, Cross-correlation, Global myocardial ischaemia, Hierarchical clustering, Spatio-temporal systems, Electrophysiologic Techniques, Cardiac, Female, Humans, Male, Myocardial Ischemia, Pericardium, Ventricular Fibrillation