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We provide two examples to illustrate the use of intersectional genetics for more precise gene targeting in vivo, namely manipulation of genes in blood vessels of the heart and brain. More broadly, this system provides a valuable strategy for tissue-specific gene manipulation that can be widely applied to other fields of biomedical research.

Original publication

DOI

10.1161/circresaha.118.312981

Type

Journal article

Journal

Circulation Research

Publisher

Lippincott Williams & Wilkins Ltd.

Publication Date

15/05/2018

Addresses

Key Laboratory of Nutrition and Metabolism, Shanghai Institutes for Biological Sciences.