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We provide two examples to illustrate the use of intersectional genetics for more precise gene targeting in vivo, namely manipulation of genes in blood vessels of the heart and brain. More broadly, this system provides a valuable strategy for tissue-specific gene manipulation that can be widely applied to other fields of biomedical research.

Original publication




Journal article


Circulation Research


Lippincott Williams & Wilkins Ltd.

Publication Date



Key Laboratory of Nutrition and Metabolism, Shanghai Institutes for Biological Sciences.