Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The Ca2+ channel antagonists nifedipine and verapamil each significantly inhibited (50-100%) the smooth muscle contraction induced in response to either 5-hydroxytryptamine (1 microM, 5-HT) or 20 mM K+ (K(+)-physiological salt solution) in the basilar artery. Simultaneous measurements of smooth muscle membrane potential showed that changes in potential were not modified at this time. A similar inhibitory action against the smooth muscle contraction but not the depolarization to 5-HT was obtained with the putative protein kinase C and phospholipase C inhibitors, 1-(5-isoquinolinesulphonyl)-2-methylpiperazine (10 microM, H7) and 2-nitro-4-carboxyphenyl-N,N-diphenylcarbamate (70 microM, NCDC). These data indicate that 5-HT-induced Ca2+ influx through voltage sensitive channels is important for smooth muscle contraction but not depolarization in the rabbit basilar artery.

Original publication




Journal article


Eur J Pharmacol

Publication Date





113 - 116


1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine, Animals, Basilar Artery, Calcium Channel Blockers, Carbamates, Female, Isoquinolines, Male, Membrane Potentials, Muscle Contraction, Muscle, Smooth, Vascular, Nifedipine, Phenylcarbamates, Piperazines, Potassium, Protein Kinase C, Rabbits, Serotonin, Type C Phospholipases, Verapamil