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Noradrenaline and adrenaline (via beta-receptors), adenosine, and prostacyclin all relaxed inner more than outer muscle in coronary arteries contracted by histamine. In submaximal concentrations, noradrenaline, and usually the other dilator hormones, produced proportionately even greater relaxation of inner than outer muscle. Inner and outer strips contracted by 5-hydroxytryptamine showed similar but smaller differences in response to noradrenaline. Outer strips contracted by methacholine were little affected by noradrenaline, though inorganic nitrite relaxed them.

Original publication




Journal article


Eur J Pharmacol

Publication Date





327 - 330


Adenosine, Animals, Cattle, Coronary Vessels, Epinephrine, Epoprostenol, Histamine, In Vitro Techniques, Muscle Contraction, Muscle, Smooth, Vascular, Norepinephrine, Sodium Nitrite, Vasodilator Agents