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Although the role of the Cdk5 protein in Alzheimer's disease (AD) is well recognized, there have been relatively few studies investigating genetic variants in the CDK5 gene in AD. In this study, we assessed the association between five previously described single nucleotide polymorphisms (SNPs) in the CDK5 gene and late onset AD by means of logistic regression and haplotype association analyses. Including all prevalent and incident AD cases, we found a significantly increased risk of AD for carriers of the GG genotype of SNP rs2069442 (OR = 1.79, 95 % CI 1.16-2.79, p = 0.001) in those without APOE*4. When limiting the analysis to incident cases without APOE*4, carriers of the GG genotype showed a 1.9-fold increased risk of AD (95 % CI 1.16-3.10, p = 0.003). Variations in the CDK5 gene can be described in 5 haplotype blocks. In our analysis, the haplotype tagged by the G allele of SNP rs2069442 was significantly associated with AD (p = 0.05). In conclusion, our study suggests that CDK5 may be associated with AD.

Original publication

DOI

10.1007/s00415-008-0770-5

Type

Journal article

Journal

J Neurol

Publication Date

05/2008

Volume

255

Pages

655 - 662

Keywords

Aged, Alzheimer Disease, Brain, Cyclin-Dependent Kinase 5, DNA Mutational Analysis, Female, Genetic Markers, Genetic Predisposition to Disease, Genetic Testing, Genotype, Haplotypes, Humans, Incidence, Male, Netherlands, Polymorphism, Single Nucleotide, Prevalence, Risk Factors