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Studies of risk factors for Alzheimer's disease have been hampered by low statistical power. The data from 11 case-control studies were pooled and re-analysed to evaluate the evidence for the association of Alzheimer's disease with family history of dementia and related disorders, parental age, medical history, and environmental factors. This paper gives a brief description of the participating studies and discusses the strategy that has been followed in the collaborative analysis.

Original publication




Journal article


Int J Epidemiol

Publication Date



20 Suppl 2


S4 - 12


Adult, Aged, Alzheimer Disease, Australia, Case-Control Studies, Europe, Female, Humans, Male, Meta-Analysis as Topic, Middle Aged, Risk Factors, United States