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BACKGROUND AND DESIGN: The effect of the cholesteryl ester transfer protein (CETP) I405V polymorphism on lipid levels, atherosclerosis and myocardial infarction (MI) was examined in 6421 participants from the Rotterdam Study. METHODS: Quantitative outcomes were studied with linear models; Cox models were used to assess MI risk. RESULTS: High-density lipoprotein cholesterol (HDL) increased by 0.06 [95% confidence interval (CI): 0.03, 0.09] mmol/l in VV carriers. The V allele was further associated with decreased MI risk in men [hazard ratio (95% confidence interval)=0.57 (0.45, 0.73), VV versus II] (Ptrend=0.02). CONCLUSION: This study provides additional evidence for the association of CETP with HDL levels and suggests that CETP is an atherogenic protein increasing the risk of MI.

Original publication




Journal article


Eur J Cardiovasc Prev Rehabil

Publication Date





419 - 421


Atherosclerosis, Cholesterol Ester Transfer Proteins, Female, Follow-Up Studies, Gene Frequency, Genetic Predisposition to Disease, Humans, Incidence, Linear Models, Lipoproteins, HDL, Male, Middle Aged, Myocardial Infarction, Netherlands, Polymorphism, Genetic, Population Surveillance, Proportional Hazards Models, Prospective Studies, Risk Assessment, Risk Factors, Sex Factors, Time Factors, Up-Regulation